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CARMEL, Ind., April 05, 2022 — MBX Biosciences, Inc., a clinical stage biopharmaceutical company developing peptide therapeutics with a focus on the treatment of endocrine disorders, today announced the appointment of Ora Hirsch Pescovitz, M.D., to its Board of Directors. Dr. Pescovitz currently serves as President of Oakland University, a public university in Michigan with over 17,000 students. She is a renowned academic leader, health care executive, pediatric endocrinologist and researcher, and has published extensively.

“With a deep background in pediatric endocrinology and years of academic, medical and business leadership, Ora brings a valuable perspective to the Board as we continue to advance our pipeline of Precision Endocrine Peptides,” said Kent Hawryluk, President and Chief Executive Officer of MBX Biosciences. “On behalf of MBX Biosciences and our Board of Directors, we welcome her to this role and look forward to drawing upon Ora’s strategic and medical acumen as we strive to fulfill our mission of bringing new treatment options to people with endocrine disorders.”

Prior to being named President of Oakland University, Dr. Pescovitz served as Senior Vice President and U.S. Medical Leader for Lilly Biomedicines at Eli Lilly and Company from 2014 to 2017. From 2009 to 2014, she was the University of Michigan’s first female Executive Vice President for Medical Affairs and Health System CEO. During this time, she led a system that included three hospitals, more than 120 health centers and clinics, and the University of Michigan Medical School, and was elected to the National Academy of Medicine. She has also held numerous leadership positions with a broad range of medical research, healthcare, and civic organizations, including president of the Society for Pediatric Research, president of the Lawson Wilkins (North American) Pediatric Endocrine Society, and chair of the March of Dimes Grants Review Committee. She earned her M.D. from the Northwestern University Feinberg School of Medicine, where she has earned Distinguished Alumni Awards from both the Feinberg School of Medicine and Northwestern University.

“I am pleased to join the MBX Board of Directors at this transformational time, as the company continues to build on the expanding foundation of its endocrine-focused clinical and preclinical pipeline,” said Dr. Pescovitz. “I look forward to contributing to their continued progress and success.”

About MBX Biosciences

MBX Biosciences, Inc. is a clinical stage biopharmaceutical company pioneering investigational Precision Endocrine Peptides (PEPs™). PEPs are designed to overcome key limitations of native peptide therapeutics to deliver superior pharmacologic properties. MBX is advancing a pipeline of PEP candidates to address the unmet needs of people with endocrine disorders. The company’s lead product candidate, MBX 2109 for the treatment of hypoparathyroidism, is currently in a Phase 1 clinical trial. Members of MBX’s leadership team have collaborated over several decades on the discovery, development, and commercialization of highly successful endocrine therapeutics including Forteo^® and Humalog^®. The company is supported by leading life science investors including Frazier Life Sciences, New Enterprise Associates and OrbiMed. For more information, please visit www.mbxbio.com or follow-us on LinkedIn.

Media Inquiries:

Ian Stone
Canale Communications
[email protected]
619-849-5388

Investor Inquiries:

Robert Uhl
ICR Westwicke
[email protected]
619.228.5886

CARMEL, Ind.—January 5, 2021 – MBX Biosciences, a drug discovery company focused on rare endocrine diseases, today announced the appointment of Mary Jane Geiger, M.D., Ph.D., FACP, FAHA, to the newly created role of chief medical officer. Dr. Geiger will oversee MBX’s global clinical drug development, bringing more than 20 years’ experience in clinical drug development and supporting multiple successful drug registrations.

“Mary Jane’s range of experience taking treatments through clinical studies to registration makes her an ideal addition to our team,” said Kent Hawryluk, president and chief executive officer of MBX Biosciences. “Her demonstrated creativity in clinical trial design and strong clinical research background complement our organization’s expertise. She will play a leading role in MBX’s transition into a clinical-stage company.”

Prior to joining MBX, Dr. Geiger served as vice president, drug development services – cardiovascular, at ICON, a global clinical research organization. She provided cardio-metabolic and renal therapeutic area and rare disease consulting and drug development expertise to pharmaceutical and biotech clients, assisting them in the successful development and delivery of their drug development portfolios. Dr. Geiger previously served as senior director, cardiovascular and metabolism at Regeneron Pharmaceuticals, a publicly-traded biopharmaceutical company; as vice president, clinical development at Relypsa, a private pharmaceutical company; and as medical fellow I, Lilly Diabetes at Eli Lilly and Company. During her tenure at Lilly, Dr. Geiger was responsible for clinical development of Trulicity® from post-Phase 1 through completion of pivotal clinical studies. She began her biopharmaceutical industry career at Merck in 2000, and before this was in private practice, a clinical trial investigator, IRB member and chairman of the department of internal medicine. She has served as co-chair, scientific oversight committee, of the Cardiac Safety Research Consortium, a public-private partnership focused on the evaluation of cardiac safety of medical products, since 2015. Dr. Geiger earned her bachelor’s degree in biology from Marquette University and her medical doctorate and Ph.D. from the Medical College of Wisconsin in Milwaukee, Wisconsin. She completed her internal medicine internship and residency at Duke University Medical Center with additional research in nephrology and cardiology, and she has authored numerous scientific and clinical publications.

“MBX’s technology offers differentiated solutions to address unmet medical needs in rare endocrine disease,” said Dr. Geiger. “I am excited to join MBX’s proven team and help advance the company’s pipeline through clinical development, registration and commercialization.”

About MBX Biosciences
MBX Biosciences is a biotechnology company creating therapies for rare endocrine diseases. Members of MBX’s leadership team previously collaborated in the creation of highly successful endocrine drugs (Humalog®, Forteo®) and three Indiana-based companies (Marcadia, Calibrium and MB2). MBX is strengthened by world-class proprietary technology and drug candidates licensed from the DiMarchi Indiana University laboratory. The company is supported by investment from leading life science investors that include Frazier Healthcare Partners, OrbiMed, and New Enterprise Associates. For more information, please visit mbxbio.com.

Contacts

Ian Stone
Canale Communications
[email protected]
619-849-5388

Industry veteran brings deep experience growing companies, including as chairman and CEO of Bristol Myers Squibb, and as board member and CFO of Eli Lilly

CARMEL, Ind.– October 27, 2020 — MBX Biosciences, a drug discovery company focused in rare
endocrine diseases, today announced the appointment of James Cornelius to its board of directors.

“Jim Cornelius is among the most accomplished global biopharmaceutical executives, and he is recognized for decades of leadership with highly successful organizations,” said Kent Hawryluk, president and chief executive officer of MBX Biosciences. “His insight and perspective as part of our board of directors will be invaluable as we continue to build a leading rare disease company.”

Mr. Cornelius served as chairman of the board of directors of Bristol Myers Squibb (BMY) from February 2008 to May 2015, as well as BMY’s chief executive officer from September 2006 to March 2010. Under his leadership, BMY successfully completed a transformation into a leading specialty biopharmaceutical enterprise. He served as chairman of the board of Mead Johnson Nutrition from December 2009 to June 2017 when it was acquired by Reckitt Benckiser for $16 billion. Mr. Cornelius served as board chairman and chief executive officer of Guidant from November 2005 to April 2006 when it was acquired by Boston Scientific for $27 billion. He was executive chairman of the board of Guidant Corporation and its senior executive beginning in September 1994 when the company was formed within Eli Lilly (LLY). Mr. Cornelius was a member of LLY’s board of directors and its chief financial officer from 1983 until 1995. He has served on the board of directors of a dozen private and public companies, including The Chubb Corporation, The DIRECTV Group and Given Imaging. Mr. Cornelius is currently chairman of Cornelius Family Foundation and Cornelius Private Investments. He has served the United Way of Central Indiana in multiple leadership positions, and he has received several honorary doctorate degrees and achievement awards. He earned a bachelor’s degree magna cum laude and an MBA from Michigan State University.

“MBX’s therapeutic programs in rare endocrine diseases address significant unmet need,” said Mr. Cornelius. “I have worked with several MBX team members previously, including Kent Hawryluk and Richard DiMarchi, and I am impressed with the team, investor syndicate and technology they have assembled. I look forward to helping realize the company’s outstanding potential.”

About MBX Biosciences
MBX Biosciences is a biotechnology company creating therapies for rare endocrine diseases. Members of MBX’s leadership team previously collaborated in the creation of highly successful endocrine drugs (Humalog®, Forteo®) and three Indiana-based companies (Marcadia, Calibrium and MB2). MBX is strengthened by world-class proprietary technology and drug candidates licensed from the DiMarchi Indiana University laboratory. The company is supported by investment from leading life science investors that include Frazier Healthcare Partners, OrbiMed, and New Enterprise Associates. For more information, please visit mbxbio.com.

Contacts

Media Inquiries:
Ian Stone
Canale Communications
[email protected]
619-849-5388

Financing led by Frazier Healthcare Partners with Participation from OrbiMed and New Enterprise Associates

CARMEL, Ind.- July 27, 2020 – MBX Biosciences, a drug discovery company focused in rare endocrine diseases, today announced the closing of a $34.6 million Series A financing. The financing was led by Frazier Healthcare Partners, with participation from OrbiMed, New Enterprise Associates, Indiana Philanthropic Venture Fund (IU PhV), Indiana Seed Fund III (managed by BioCrossroads) and Twilight Venture Partners II.

Proceeds of the financing will support MBX as it advances its preclinical pipeline of peptide therapeutic candidates directed at clinically validated molecular targets. The company is built upon the medicinal expertise and chemical technologies invented at the Indiana University laboratory of Professor Richard DiMarchi, Ph.D., co-founder and chief scientific officer of MBX. The company seeks to address rare endocrine disorders with substantial unmet medical need.

“With the support of these leading life science investors, we are equipped to advance our drug candidates toward clinical investigation in underserved disease areas,” said Kent Hawryluk, president and chief executive officer of MBX. “We are excited to assemble a team with a proven track record in discovering and developing novel drugs to address unmet medical needs.”

In conjunction with the financing, MBX has appointed three new members to its board of directors: Patrick Heron, managing partner of Frazier Healthcare Partners; Carl Gordon, Ph.D., managing partner of OrbiMed; and Ed Mathers, general partner of New Enterprise Associates. They join Mr. Hawryluk and Dr. DiMarchi.

“Following the successful history of Marcadia Biotech and Calibrium with Richard and Kent, Frazier is proud to fund the next stage of MBX’s development,” said Mr. Heron. “Together with OrbiMed and NEA, we look forward to helping build another world-class drug development company in Indianapolis with this leadership team.”

About MBX Biosciences
MBX Biosciences is a biotechnology company creating therapies for rare endocrine diseases. Members of MBX’s leadership team previously collaborated in the creation of highly successful endocrine drugs (Humalog®, Forteo®) and three Indiana-based companies (Marcadia, Calibrium and MB2). MBX is strengthened by world-class proprietary technology and drug candidates licensed from the DiMarchi Indiana University laboratory. The company is supported by investment from leading life science investors that include Frazier Healthcare Partners, OrbiMed, and New Enterprise Associates. For more information, please visit mbxbio.com.

Contacts

Mari Purpura, Ph.D.
Canale Communications
[email protected]